Well this will eliminate 98% of those obnoxious little knots!
Step 1: Thread your needle leaving about a 2 inch tail as you see in the image below.
Step 2: As close as you can get to the needle on the 2 inch tail (or longer if you need) pierce the tail with the needle but do not pull it through the thread.
Step 3: Then do this again a little further up on the tail.
Step 4: Then do this one more time (yes one more time) a little further down on the tail. :)
Step 5: Now slide the first pierce you made down to the eye of the needle and pull on the working thread (the other end not the 2 inch tail) slightly to straighten it.
Step 6: And Finally pull the other two piercings down past the needle using your index finger and thumb and then straighten and smooth it with your fingers till you do not feel any knots. that is all there is to it.
Oh and now enjoy doing needle turned applique or sewing your binding on or what ever hand work you have handy without the constant untangling of those nasty little knots!
If this was useful to you. Please share it with a friend so they too can keep their hair in tact :)